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The results indicated that berberine was more concentrated in RBCs than in plasma and the maximum concentration of drug loading was 0.185 g/mL, while higher concentrations have been associated with hemolysis

For example, EA was conjugated to 2-amino-2-deoxy-d-glucose (EAG) 90 , obtaining an adduct with significant anticancer activity such as EA but without the undesired diuretic activity 90

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The signicant reduction in GSH selectively in the brain regions (frontal cortex and P.K